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Augment

Tab. Augment 250 mg + 125 mg

SKU PRO-03-0002929
Dosage Tab.
Brand Name Augment
Generic Amoxicillin + Clavulanic Acid
Strength 250 mg + 125 mg
Manufacturer Eskayef
Pack Piece MRP ARTO Price
Single 1 20.00 BDT 20 BDT
Box 18 pcs 360.00 BDT 360 BDT
Cartoon X X X

Information: Tab. Augment 250 mg + 125 mg

Therapeutic action – Combination of two antibacterials. The addition of clavulanic acid to amoxicillin extends its spectrum of activity to cover beta-lactamase producing Gram-positive and Gram-negative organisms, including some Gram-negative anaerobes. Indications – Animal bites, if antibiotic therapy or antibiotic prophylaxis is clearly indicated – Second line treatment of acute otitis media and acute bacterial sinusitis, when amoxicillin alone given at high dose failed – Acute uncomplicated cystitis (no systemic signs) in girls > 2 years – Postpartum upper genital tract infection – Severe pneumonia: parenteral to oral switch therapy in patients treated with ceftriaxone + cloxacillin Presentation – The ratio of amoxicillin and clavulanic acid varies according to the manufacturer: Ratio 8:1 – 500 mg amoxicillin/62.5 mg clavulanic acid tablet – 500 mg amoxicillin/62.5 mg clavulanic acid/5 ml powder for oral suspension Ratio 7:1 – 875 mg amoxicillin/125 mg clavulanic acid tablet – 400 mg amoxicillin/57 mg clavulanic acid/5 ml, powder for oral suspension Ratio 4:1 – 500 mg amoxicillin/125 mg clavulanic acid tablet – 125 mg amoxicillin/31.25 mg clavulanic acid/5 ml, powder for oral suspension Also comes in formultions with a ratio amoxicillin/clavulanic acid of 16:1, 14:1, 6:1, 2:1. Dosage (expressed in amoxicillin) – Animal bites; second line treatment of acute otitis media and acute sinusitis • Child < 40 kg: 45 to 50 mg/kg/day in 2 divided doses (if using ratio 8:1 or 7:1) or in 3 divided doses (if using ratio 4:1) Note: the dose of clavulanic acid should not exceed 12.5 mg/kg/day or 375 mg/day. • Child ≥ 40 kg and adult: 1500 to 2000 mg/day depending on the formulation available: Ratio 8:1: 2000 mg/day = 2 tablets of 500/62.5 mg 2 times per day Ratio 7:1: 1750 mg/day = 1 tablet of 875/125 mg 2 times per day Ratio 4:1: 1500 mg/day = 1 tablet of 500/125 mg 3 times per day Note: the dose of clavulanic acid should not exceed 375 mg/day. – Acute uncomplicated cystitis in girls > 2 years 25 mg/kg/day in 2 divided doses (if using ratio 8:1 or 7:1 or 4:1) Note: the dose of clavulanic acid should not exceed 12.5 mg/kg/day or 375 mg/day. – Postpartum upper genital tract infection; parenteral to oral switch therapy in severe pneumonia Use formulations with a ratio 8:1 or 7:1: • Child < 40 kg: 80 to 100 mg/kg/day in 2 or 3 divided doses Note: the dose of clavulanic acid should not exceed 12.5 mg/kg/day or 375 mg/day. • Child ≥ 40 kg and adult: 2500 to 3000 mg/day in 3 divided doses. Depending on the formulation available: Ratio 8:1: 3000 mg/day = 2 tablets of 500/62.5 mg 3 times per day Ratio 7:1: 2625 mg/day = 1 tablet of 875/125 mg 3 times per day Note: the dose of clavulanic acid should not exceed 375 mg/day. Duration – Animal bites: 5 to 7 days; otitis media: 5 days; sinusitis: 7 to 10 days; cystitis: 3 days; upper genital tract infection: 7 days; parenteral to oral switch therapy in severe pneunonia: to complete a total of 10 to 14 days of treatment. Contra-indications, adverse effects, precautions – Do not administer to penicillin-allergic patients and patients with history of hepatic disorders during a previous treatment with co-amoxiclav. – Administer with caution to patients allergic to cephalosporins (cross-sensitivity may occur). – Administer with caution to patients with hepatic impairment; reduce dosage and give every 12 to 24 hours in patients with severe renal impairment. – May cause: gastrointestinal disturbances (mainly diarrhoea); allergic reactions sometimes severe (stop treatment immediately); jaundice and cholestatic hepatitis in the event of prolonged treatment (> 10 to 15 days). – Pregnancy: no contra-indication – Breast-feeding: no contra-indication Remarks – High doses of co-amoxiclav (80-100 mg/kg/day or 2.5-3 g/day) cannot be administered when using formulations of amoxicillin/clavulanic acid in a ratio of 4:1 (the content in clavulanic acid is too high). The maximum dose (expressed in amoxicillin) that can be given with these formulations is 50 mg/kg/day, without exceeding 1500 mg/day. – Take with meals. – Storage: below 25°C – – Powder for oral suspension: between 15°C and 25°C Once reconstituted, the oral suspension must be kept refrigerated (between 2°C and 8°C) and may be used for up to 7 days. https://medlineplus.gov/druginfo/meds/a685024.html https://en.wikipedia.org/wiki/Amoxicillin

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